As we age our NAD+ levels decrease, and scientists now believe this is linked to aging. The rate of decline is greater than the body's own natural ability to replace NAD+. Studies on old mice have shown that some biomarkers of aging can actually be reversed by giving them NMN supplements to boost NAD+ levels.
Why is NAD+ so critical?
NAD+ is important for three main functions in the body: producing energy, activating "longevity genes" called SIRTUINS, and repairing DNA. SIRTUINS cannot work without enough NAD+. NAD+ is also used to help repair broken DNA strands, which maintains the integrity of the genetic code by protecting against mutations.
What causes NAD+ levels to fall?
NAD+ levels decrease because NAD+ is used by enzymes like SIRTUINS, DNA-repair enzymes, and aggressively by ecto-enzyme CD38. CD38 is the greatest destroyer of NAD+ in the body, driven by Inflammatory cytokines and Senescent cells. Eventually, more NAD+ is used up than can be replenished, contributing to the over-all decline that is experienced with aging.
It is now clear that supporting NAD+ levels is important for promoting good health, especially as we age.
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We use Pharmaceutical Grade, 99% Pure micron-sized particle Trans-Resveratrol Extract with BioPerine® for Superior Performance. (All-natural purified polygonum cuspidatum root extract)
Resveratrol is one of the most powerful naturally occurring compound that can directly turn on our longevity-genes called SIRTUINS. SIRTUINS are the NAD+ dependent longevity-genes, that when activated, for example by caloric-restriction, has been shown to extend lifespan in many animal models. Resveratrol also has a positive impact on all three major longevity pathways SIRTUINS, mTOR and AMPK.